Direct Thiazolidinedione Action in the Human Ovary: Insulin-Independent and Insulin-Sensitizing Effects on Steroidogenesis and Insulin-Like Growth Factor Binding Protein-1 Production | Zendy

Donna SetoYoung | Zendy; Maria Paliou | Zendy; J. Schlosser | Zendy; Dimiter Avtanski | Zendy; Alice Park | Zendy; Parini Patel | Zendy; Kevin Holcomb | Zendy; Peter L. Chang | Zendy; Leonid Poretsky | Zendy

Open Access

Direct Thiazolidinedione Action in the Human Ovary: Insulin-Independent and Insulin-Sensitizing Effects on Steroidogenesis and Insulin-Like Growth Factor Binding Protein-1 Production

Author(s) -

Donna SetoYoung,

Maria Paliou,

J. Schlosser,

Dimiter Avtanski,

Alice Park,

Parini Patel,

Kevin Holcomb,

Peter L. Chang,

Leonid Poretsky

Publication year - 2005

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2005-0469

Subject(s) - rosiglitazone , medicine , endocrinology , pioglitazone , polycystic ovary , thiazolidinedione , insulin , hyperinsulinemia , testosterone (patch) , peroxisome proliferator activated receptor , biology , insulin resistance , receptor , diabetes mellitus , type 2 diabetes

Hyperinsulinemia contributes to the pathogenesis of ovarian dysfunction in insulin-resistant states, including polycystic ovary syndrome (PCOS). Peroxisome proliferator activated receptor-gamma (PPAR-gamma) agonists [thiazolidinediones (TZDs)] ameliorate hyperandrogenism in polycystic ovary syndrome presumably because they reduce systemic hyperinsulinemia. Direct effects of TZDs in the ovary, however, cannot be excluded. We explored direct effects of TZDs in cultured human ovarian cells.

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