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Two classes of repeated genomic elements, retrotransposons and endogenous retroviruses, encode for endogenous nontelomeric reverse transcriptase (RT), a gene that is down-regulated in differentiated cells but is highly expressed in embryonic and transformed tissues. Two nonnucleosidic RT inhibitors, efavirenz and nevirapine, currently used in HIV treatment, reversibly down-regulate tumor growth and induce differentiation in several human tumor cell models.

the journal of clinical endocrinology and metabolism/journal of clinical endocrinology and metabolism

Reverse Transcriptase Inhibitors Down-Regulate Cell Proliferation<i>in Vitro</i>and<i>in Vivo</i>and Restore Thyrotropin Signaling and Iodine Uptake in Human Thyroid Anaplastic Carcinoma

Reverse Transcriptase Inhibitors Down-Regulate Cell Proliferationin Vitroandin Vivoand Restore Thyrotropin Signaling and Iodine Uptake in Human Thyroid Anaplastic Carcinoma