Reverse Transcriptase Inhibitors Down-Regulate Cell Proliferationin Vitroandin Vivoand Restore Thyrotropin Signaling and Iodine Uptake in Human Thyroid Anaplastic Carcinoma | Zendy

Matteo Landriscina | Zendy; Annarita Fabiano | Zendy; Settimia Altamura | Zendy; Cinzia Bagalà | Zendy; Annamaria Piscazzi | Zendy; Alessandra Cassano | Zendy; Corrado Spadafora | Zendy; Francesco Giorgino | Zendy; Carlo Barone | Zendy; Mauro Cignarelli | Zendy

Open Access

Reverse Transcriptase Inhibitors Down-Regulate Cell Proliferationin Vitroandin Vivoand Restore Thyrotropin Signaling and Iodine Uptake in Human Thyroid Anaplastic Carcinoma

Author(s) -

Matteo Landriscina,

Annarita Fabiano,

Settimia Altamura,

Cinzia Bagalà,

Annamaria Piscazzi,

Alessandra Cassano,

Corrado Spadafora,

Francesco Giorgino,

Carlo Barone,

Mauro Cignarelli

Publication year - 2005

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2005-0367

Subject(s) - efavirenz , nevirapine , reverse transcriptase , retrotransposon , biology , endogenous retrovirus , cancer research , context (archaeology) , in vivo , telomerase reverse transcriptase , endogeny , cell growth , microbiology and biotechnology , virology , rna , endocrinology , gene , telomerase , virus , genetics , paleontology , transposable element , genome , viral load , antiretroviral therapy

Two classes of repeated genomic elements, retrotransposons and endogenous retroviruses, encode for endogenous nontelomeric reverse transcriptase (RT), a gene that is down-regulated in differentiated cells but is highly expressed in embryonic and transformed tissues. Two nonnucleosidic RT inhibitors, efavirenz and nevirapine, currently used in HIV treatment, reversibly down-regulate tumor growth and induce differentiation in several human tumor cell models.

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