Open AccessJoint Mechanisms of Impaired Growth-Hormone Pulse Renewal in Aging Men
Author(s) -
Johannes D. Veldhuis,
Ali Iranmanesh,
Cyril Y. Bowers
Publication year - 2005
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2005-0336
Subject(s) - endocrinology , medicine , saline , bolus (digestion) , pulse (music) , negative feedback , hormone , growth hormone , body mass index , physics , engineering , quantum mechanics , voltage , detector , electrical engineering
Aging reduces the size (mass) of GH secretory bursts and thereby reduces total GH secretion. Experimental data indicate that high-amplitude GH pulses are evoked by reversible cycles of GH-induced negative feedback. Whether aging impairs autofeedback is unknown.
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