Osteopontin Is Overexpressed in Human Papillary Thyroid Carcinomas and Enhances Thyroid Carcinoma Cell Invasiveness | Zendy

Valentina Guarino | Zendy; Pinuccia Faviana | Zendy; Giuliana Salvatore | Zendy; Maria Domenica Castellone | Zendy; Anna Maria Cirafici | Zendy; Valentina De Falco | Zendy; Angela Celetti | Zendy; Riccardo Giannini | Zendy; Fulvio Basolo | Zendy; Rosa Marina Melillo | Zendy; Massimo Santoro | Zendy

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Osteopontin Is Overexpressed in Human Papillary Thyroid Carcinomas and Enhances Thyroid Carcinoma Cell Invasiveness

Author(s) -

Valentina Guarino,

Pinuccia Faviana,

Giuliana Salvatore,

Maria Domenica Castellone,

Anna Maria Cirafici,

Valentina De Falco,

Angela Celetti,

Riccardo Giannini,

Fulvio Basolo,

Rosa Marina Melillo,

Massimo Santoro

Publication year - 2005

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2005-0271

Subject(s) - osteopontin , thyroid carcinoma , context (archaeology) , cancer research , oncogene , thyroid , transmembrane protein , glycoprotein , pathology , carcinoma , medicine , biology , cancer , cell cycle , microbiology and biotechnology , receptor , paleontology

The transmembrane glycoprotein CD44v6 is overexpressed in most papillary thyroid carcinomas (PTC). We previously reported that osteopontin (OPN), a secreted glycoprotein that functions as a ligand for CD44v6, is overexpressed in thyrocytes transformed by the RET/PTC oncogene.

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