Septic Shock and Sepsis: A Comparison of Total and Free Plasma Cortisol Levels | Zendy

J. T. Ho | Zendy; Houda S Almusalhi | Zendy; M. John Chapman | Zendy; T. Quach | Zendy; Peter Thomas | Zendy; C.J. Bagley | Zendy; John G. Lewis | Zendy; David J. Torpy | Zendy

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Septic Shock and Sepsis: A Comparison of Total and Free Plasma Cortisol Levels

Author(s) -

J. T. Ho,

Houda S Almusalhi,

M. John Chapman,

T. Quach,

Peter Thomas,

C.J. Bagley,

John G. Lewis,

David J. Torpy

Publication year - 2006

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2005-0265

Subject(s) - liter , hydrocortisone , medicine , adrenal insufficiency , sepsis , endocrinology , transcortin , basal (medicine) , convalescence , glucocorticoid , albumin , septic shock , globulin , shock (circulatory) , insulin

Severe systemic infection leads to hypercortisolism. Reduced cortisol binding proteins may accentuate the free cortisol elevations seen in systemic infection. Recently, low total cortisol increments after tetracosactrin have been associated with increased mortality and hemodynamic responsiveness to exogenous hydrocortisone in septic shock (SS), a phenomenon termed by some investigators as relative adrenal insufficiency (RAI).

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