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Despite having increased knowledge of the adverse reproductive effects of smoking, it is unclear whether nicotine affects the pulsatile LH secretion in humans. We addressed this issue in male and female smokers and nonsmokers.

the journal of clinical endocrinology and metabolism/journal of clinical endocrinology and metabolism

Nicotine Inhibits Pulsatile Luteinizing Hormone Secretion in Human Males But Not in Human Females, and Tolerance to This Nicotine Effect Is Lost within One Week of Quitting Smoking