Ghrelin Does Not Stimulate Food Intake in Patients with Surgical Procedures Involving Vagotomy | Zendy

Carel W. le Roux | Zendy; Nicola M. Neary | Zendy; Tim Halsey | Zendy; C. J. Small | Zendy; Alberto Isla | Zendy; Mohammad A. Ghatei | Zendy; N A Theodorou | Zendy; Stephen R. Bloom | Zendy

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Ghrelin Does Not Stimulate Food Intake in Patients with Surgical Procedures Involving Vagotomy

Author(s) -

Carel W. le Roux,

Nicola M. Neary,

Tim Halsey,

C. J. Small,

Alberto Isla,

Mohammad A. Ghatei,

N A Theodorou,

Stephen R. Bloom

Publication year - 2005

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2004-2537

Subject(s) - ghrelin , vagotomy , appetite , medicine , endocrinology , vagus nerve , meal , saline , stomach , hormone , stimulation

Patients with gastric or esophageal surgery and transection of the vagus nerve may suffer from appetite and weight loss but without dysphagia or mechanical obstruction to eating. The gastric hormone ghrelin stimulates food intake and GH release in rodents and man. However, rodents with vagotomy are not sensitive to the feeding effects of ghrelin.

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