Bone Mineral and Collagen Quality in Iliac Crest Biopsies of Patients Given Teriparatide: New Results from the Fracture Prevention Trial | Zendy

Eleftherios P. Paschalis | Zendy; Emmett V. Glass | Zendy; David W. Donley | Zendy; Erik Fink Eriksen | Zendy

Open Access

Bone Mineral and Collagen Quality in Iliac Crest Biopsies of Patients Given Teriparatide: New Results from the Fracture Prevention Trial

Author(s) -

Eleftherios P. Paschalis,

Emmett V. Glass,

David W. Donley,

Erik Fink Eriksen

Publication year - 2005

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2004-2489

Subject(s) - teriparatide , pyridinoline , bone mineral , medicine , osteoporosis , endocrinology , iliac crest , type i collagen , placebo , urology , dentistry , surgery , chemistry , pathology , alkaline phosphatase , osteocalcin , biochemistry , alternative medicine , enzyme

Evidence suggests that both bone mineral density and bone quality should be taken into account when assessing bone strength and fracture risk. Bone quality is a multifactor entity, of which bone architecture and material properties are two important components. Matrix mineralization, hydroxyapatite characteristics, and collagen cross-link ratio are key determinants of material properties. Fourier transform infrared imaging (FTIRI) yields data on these characteristics from bone sections.

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