Reproducibility of Nighttime Salivary Cortisol and Its Use in the Diagnosis of Hypercortisolism Compared with Urinary Free Cortisol and Overnight Dexamethasone Suppression Test | Zendy

Alexander Viardot | Zendy; Peter Huber | Zendy; Jardena J. Puder | Zendy; Henryk Zulewski | Zendy; Ulrich Keller | Zendy; Beat P. MüllerStich | Zendy

Open Access

Reproducibility of Nighttime Salivary Cortisol and Its Use in the Diagnosis of Hypercortisolism Compared with Urinary Free Cortisol and Overnight Dexamethasone Suppression Test

Author(s) -

Alexander Viardot,

Peter Huber,

Jardena J. Puder,

Henryk Zulewski,

Ulrich Keller,

Beat P. MüllerStich

Publication year - 2005

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2004-2264

Subject(s) - reproducibility , medicine , dexamethasone suppression test , receiver operating characteristic , intraclass correlation , dexamethasone , cutoff , urinary system , area under the curve , endocrinology , hydrocortisone , creatinine , confidence interval , glucocorticoid , chemistry , physics , chromatography , quantum mechanics

Nighttime salivary cortisol (NSC) has been suggested to be a useful diagnostic test for Cushing's syndrome (CS). In the absence of published data on its day-to-day variability, we assessed the reproducibility of NSC by repeated measurements in healthy volunteers. Its diagnostic performance was compared with 24-h urinary free cortisol (UFC) and 1 mg overnight dexamethasone suppression test in 12 patients with CS, 20 healthy volunteers, 14 referred patients in which CS was excluded or not firmly established, 16 obese patients, and 20 women in late pregnancy.

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