Estrogen Receptor-Related Receptor α: A Mediator of Estrogen Response in Bone | Zendy

Edith Bonnelye | Zendy; Jane E. Aubin | Zendy

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Estrogen Receptor-Related Receptor α: A Mediator of Estrogen Response in Bone

Author(s) -

Edith Bonnelye,

Jane E. Aubin

Publication year - 2005

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2004-2168

Subject(s) - estrogen receptor , estrogen related receptor gamma , estrogen related receptor alpha , estrogen , estrogen receptor beta , estrogen receptor alpha , mediator , nuclear receptor , receptor , selective estrogen receptor modulator , endocrinology , medicine , biology , chemistry , cancer research , transcription factor , biochemistry , gene , cancer , breast cancer

Estrogen receptor-related receptor-alpha (ERRalpha) is an orphan nuclear receptor with sequence homology to the estrogen receptors, ERalpha/beta, but it does not bind estrogen. However, several recent studies suggest that ERRalpha not only plays a functional role in osteoblasts but also impinges on the estrogen axis in bone, as it does in at least certain other estrogen target tissues. We summarize here data on ERRalpha and its cellular and molecular modes of action that have broad implications for considering the potential role of this orphan receptor as a new therapeutic target in osteopenic disorders such as osteoporosis as well as other estrogen-responsive conditions.

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