Identification and Characterization of Two Novel Splicing Isoforms of Human Estrogen-Related Receptor β
Author(s) -
Wei Zhou,
Zhilin Liu,
Jianbo Wu,
Jing-Hua Liu,
Salman M. Hyder,
Eric Antoniou,
Dennis B. Lubahn
Publication year - 2006
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2004-1957
Subject(s) - gene isoform , alternative splicing , biology , rna splicing , nuclear receptor , estrogen receptor , nuclear localization sequence , microbiology and biotechnology , estrogen receptor alpha , estrogen receptor beta , gene , signal transduction , genetics , transcription factor , rna , cancer , breast cancer
Estrogen-related receptor beta (ERRbeta) was one of the first two orphan nuclear receptors reported and is believed to play important roles in estrogen-regulated pathways. Embryo lethality of ERRbeta-null mice indicated that ERRbeta is essential for embryo development.
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