Analysis of Separate and Combined Effects of Common Variation in KCNJ11 and PPARG on Risk of Type 2 Diabetes | Zendy

Sara K. Hansen | Zendy; Eva-Maria D. Nielsen | Zendy; Jakob Ek | Zendy; Gary L. Andersen | Zendy; Charlotte Glümer | Zendy; Bendix Carstensen | Zendy; Peter Mouritzen | Zendy; Thomas Drivsholm | Zendy; Knut BorchJohnsen | Zendy; Torben Jørgensen | Zendy; Torben Hansen | Zendy; Oluf Pedersen | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Analysis of Separate and Combined Effects of Common Variation in KCNJ11 and PPARG on Risk of Type 2 Diabetes

Author(s) -

Sara K. Hansen,

Eva-Maria D. Nielsen,

Jakob Ek,

Gary L. Andersen,

Charlotte Glümer,

Bendix Carstensen,

Peter Mouritzen,

Thomas Drivsholm,

Knut BorchJohnsen,

Torben Jørgensen,

Torben Hansen,

Oluf Pedersen

Publication year - 2005

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2004-1942

Subject(s) - peroxisome proliferator activated receptor gamma , type 2 diabetes , variation (astronomy) , diabetes mellitus , medicine , endocrinology , physics , receptor , peroxisome , astrophysics

The separate and combined effects of the PPARG Pro(12)Ala polymorphism and the KCNJ11 Glu(23)Lys polymorphisms on risk of type 2 diabetes were investigated in relatively large-scale, case-control studies. Separate effects of the variants were examined among 1187/1461 type 2 diabetic patients and 4791/4986 middle-aged, glucose-tolerant subjects. The combined analysis involved 1164 type 2 diabetic patients and 4733 middle-aged, glucose-tolerant subjects. In the separate analyses, the K allele of the KCNJ11 Glu(23)Lys associated with type 2 diabetes (odds ratio, 1.19; P = 0.0002), whereas the PPARG Pro(12)Ala showed no significant association with type 2 diabetes. The combined analysis indicated that the two polymorphisms acted in an additive manner to increase the risk of type 2 diabetes, and we found no evidence for a synergistic interaction between them. Analysis of a model with equal additive effects of the two variants showed that the odds ratio for type 2 diabetes increased with 1.14/risk allele (P = 0.003). Together, the two polymorphisms conferred a population-attributable risk for type 2 diabetes of 28%. In conclusion, our results showed no evidence of a synergistic interaction between the KCNJ11 Glu(23)Lys and PPARG Pro(12)Ala polymorphisms, but indicated that they may act in an additive manner to increase the risk of type 2 diabetes.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research