Sildenafil Citrate (Viagra) Enhances Vasodilatation in Fetal Growth Restriction | Zendy

Mark Wareing | Zendy; Jenny Myers | Zendy; Maureen O’Hara | Zendy; Philip N. Baker | Zendy

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Sildenafil Citrate (Viagra) Enhances Vasodilatation in Fetal Growth Restriction

Author(s) -

Mark Wareing,

Jenny Myers,

Maureen O’Hara,

Philip N. Baker

Publication year - 2005

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2004-1831

Subject(s) - sildenafil , medicine , vasoconstriction , vasodilation , endocrinology , vasopressin , uterine artery , gestation , pregnancy , biology , genetics

Fetal growth restriction (FGR) affects up to 8% of all pregnancies and has massive short-term (increased fetal morbidity and mortality) and long-term (increased incidence of cardiovascular disease in adulthood) health implications. Doppler waveform analysis of pregnancies complicated by FGR suggests compromised uteroplacental circulation and placental hypoperfusion. Our aim was to determine whether myometrial small artery function was aberrant in FGR and to assess whether sildenafil citrate could improve vasodilatation in FGR pregnancies.

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