Coincidence of Multiple Endocrine Neoplasia Types 1 and 2: Mutations in theRETProtooncogene andMEN1Tumor Suppressor Gene in a Family Presenting with Recurrent Primary Hyperparathyroidism | Zendy

Karin FrankRaue | Zendy; Susanne Rondot | Zendy; Wolfgang Hoeppner | Zendy; Peter E. Goretzki | Zendy; Friedhelm Raue | Zendy; Wieland Meng | Zendy

Open Access

Coincidence of Multiple Endocrine Neoplasia Types 1 and 2: Mutations in theRETProtooncogene andMEN1Tumor Suppressor Gene in a Family Presenting with Recurrent Primary Hyperparathyroidism

Author(s) -

Karin FrankRaue,

Susanne Rondot,

Wolfgang Hoeppner,

Peter E. Goretzki,

Friedhelm Raue,

Wieland Meng

Publication year - 2005

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2004-1759

Subject(s) - men1 , multiple endocrine neoplasia , mutation , primary hyperparathyroidism , germline mutation , cancer research , hyperparathyroidism , genetics , gene mutation , tumor suppressor gene , medicine , biology , gene , carcinogenesis

Primary hyperparathyroidism (HPT) presents as a part of inherited syndromes such as multiple endocrine neoplasia (MEN) types 1 and 2. In patients with MEN1, parathyroid hyperplasia or multiple adenomas occur in approximately 90-95%. MEN2A-related HPT is characterized by a mild hypercalcemia, which is mostly asymptomatic.

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