Major Depression Is Associated with Significant Diurnal Elevations in Plasma Interleukin-6 Levels, a Shift of Its Circadian Rhythm, and Loss of Physiological Complexity in Its Secretion: Clinical Implications | Zendy

Salvatore Alesci | Zendy; Pedro E. Martinez | Zendy; Sujata Kelkar | Zendy; Ιoannis Ilias | Zendy; Donna Ronsaville | Zendy; Samuel J. Listwak | Zendy; Alejandro Ayala | Zendy; Júlio Licinio | Zendy; Herman K. Gold | Zendy; Mitchel A. Kling | Zendy; George P. Chrousos | Zendy; Philip W. Gold | Zendy

Open Access

Major Depression Is Associated with Significant Diurnal Elevations in Plasma Interleukin-6 Levels, a Shift of Its Circadian Rhythm, and Loss of Physiological Complexity in Its Secretion: Clinical Implications

Author(s) -

Salvatore Alesci,

Pedro E. Martinez,

Sujata Kelkar,

Ιoannis Ilias,

Donna Ronsaville,

Samuel J. Listwak,

Alejandro Ayala,

Júlio Licinio,

Herman K. Gold,

Mitchel A. Kling,

George P. Chrousos,

Philip W. Gold

Publication year - 2005

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2004-1667

Subject(s) - circadian rhythm , medicine , major depressive disorder , endocrinology , psychology , body mass index , amygdala

Major depressive disorder (MDD) is associated with increased risk for premature coronary heart disease and bone loss. Single time measurements of plasma IL-6, a good predictor of future risk for both cardiovascular disease and osteoporosis, revealed significant elevations in depressed patients. The objective of this study was to rigorously compare plasma IL-6 levels, measured over 24 h, in MDD patients and healthy controls. Given the activating role of IL-6 on the hypothalamic-pituitary-adrenal (HPA) axis, and the relevance of its dysregulation in MDD, we also analyzed the relations between IL-6 and cortisol levels.

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