Glucocorticoids Decrease Thyrotropin-Releasing Hormone Messenger Ribonucleic Acid Expression in the Paraventricular Nucleus of the Human Hypothalamus | Zendy

Anneke Alkemade | Zendy; Unga A. Unmehopa | Zendy; Wilmar M. Wiersinga | Zendy; Dick F. Swaab | Zendy; Eric Fliers | Zendy

Open Access

Glucocorticoids Decrease Thyrotropin-Releasing Hormone Messenger Ribonucleic Acid Expression in the Paraventricular Nucleus of the Human Hypothalamus

Author(s) -

Anneke Alkemade,

Unga A. Unmehopa,

Wilmar M. Wiersinga,

Dick F. Swaab,

Eric Fliers

Publication year - 2005

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2004-1430

Subject(s) - endocrinology , medicine , hypothalamus , in situ hybridization , messenger rna , thyrotropin releasing hormone , hormone , gene expression , depression (economics) , biology , gene , biochemistry , macroeconomics , economics

The way glucocorticoids affect TRH mRNA expression in the paraventricular nucleus of the hypothalamus is still unclear. In view of its relevance for Cushing's syndrome and depression, we measured TRH mRNA expression in human hypothalami obtained at autopsy by means of quantitative TRH mRNA in situ hybridization. In corticosteroid-treated subjects (n = 10), TRH mRNA hybridization signal was decreased as compared with matched control subjects (n = 10) (Mann-Whitney U test, P = 0.02). By inference, hypercortisolism as present in patients with Cushing's syndrome or major depression may contribute to lower serum TSH or symptoms of depression by lowering hypothalamic TRH expression.

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