Decreased Plasma Adiponectin Concentrations Are Closely Related to Steatosis in Hepatitis C Virus-Infected Patients | Zendy

JeanMichel Petit | Zendy; Anne Minello | Zendy; Valérie Jooste | Zendy; JeanBaptiste Bour | Zendy; F. Galland | Zendy; Laurence Duvillard | Zendy; Bruno Vergès | Zendy; Niels Olivier Olsson | Zendy; Philippe Gambert | Zendy; Patrick Hillon | Zendy

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Decreased Plasma Adiponectin Concentrations Are Closely Related to Steatosis in Hepatitis C Virus-Infected Patients

Author(s) -

JeanMichel Petit,

Anne Minello,

Valérie Jooste,

JeanBaptiste Bour,

F. Galland,

Laurence Duvillard,

Bruno Vergès,

Niels Olivier Olsson,

Philippe Gambert,

Patrick Hillon

Publication year - 2005

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2004-1266

Subject(s) - steatosis , medicine , adipokine , adiponectin , endocrinology , leptin , body mass index , hepatitis c virus , hepatitis c , insulin , insulin resistance , obesity , immunology , virus

The mechanisms underlying steatosis during hepatitis C virus (HCV) infection are complex and multifactorial. Obesity is a well-recognized risk factor for the development of steatosis in chronic hepatitis C infection. The aim of our study was to investigate the role of adipocytokines in HCV-related steatosis. Therefore, we hypothesized that the endocrine function of adipose tissue could be, in part, responsible for HCV-related steatosis. Seventy-one consecutive untreated chronic hepatitis C patients were studied to assess the effects of adipocytokines, body mass index (BMI), age, and HCV genotype on steatosis. We used ELISA to determine serum adiponectin, leptin, and soluble TNF receptors I and II concentrations.

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