Circulating Endothelial Progenitor Cells during Human Pregnancy | Zendy

Junichi Sugawara | Zendy; Minori MitsuiSaito | Zendy; Tetsuro Hoshiai | Zendy; Chika Hayashi | Zendy; Yoshitaka Kimura | Zendy; Kunihiro Okamura | Zendy

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Circulating Endothelial Progenitor Cells during Human Pregnancy

Author(s) -

Junichi Sugawara,

Minori MitsuiSaito,

Tetsuro Hoshiai,

Chika Hayashi,

Yoshitaka Kimura,

Kunihiro Okamura

Publication year - 2005

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2004-0541

Subject(s) - progenitor cell , homeostasis , gestation , progenitor , medicine , pregnancy , endocrinology , stem cell , biology , andrology , microbiology and biotechnology , genetics

The precise molecular and cellular mechanisms that regulate maternal vascular development during gestation are largely unknown. Endothelial progenitor cells (EPCs), which play an important role in vascular homeostasis, have been discovered in the circulation. We examined the level of circulating EPCs throughout uncomplicated pregnancies (n = 20) and assessed the correlation between serum estradiol levels and the number of EPCs. The number of circulating EPCs increased gradually and paralleled the progression of gestational age. In addition, the number of EPCs correlated significantly with the level of serum estradiol. The present study suggests that EPCs may play an important role in the regulation and maintenance of the placental development and vascular integrity during pregnancy.

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