Proopiomelanocortin and Energy Balance: Insights from Human and Murine Genetics | Zendy

Anthony P. Coll | Zendy; I. Sadaf Farooqi | Zendy; Benjamin Challis | Zendy; Giles S.H. Yeo | Zendy; Stephen O’Rahilly | Zendy

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Proopiomelanocortin and Energy Balance: Insights from Human and Murine Genetics

Author(s) -

Anthony P. Coll,

I. Sadaf Farooqi,

Benjamin Challis,

Giles S.H. Yeo,

Stephen O’Rahilly

Publication year - 2004

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2004-0428

Subject(s) - proopiomelanocortin , melanocortin , endocrinology , medicine , energy homeostasis , hypothalamus , melanocortins , biology , prohormone , homeostasis , hormone , obesity

Proopiomelanocortin (POMC) undergoes extensive and tissuespecific posttranslational processing to yield a range of biologically active peptides. Historically, the most clearly defined roles of these peptides are in the control of adrenal steroidogenesis by corticotroph-derived ACTH and skin pigmentation by αMSH. However, a rapidly expanding body of work has established that POMC-derived peptides synthesized in neurons of the hypothalamus play a central role in the control of energy homeostasis. We review how inherited abnormalities in POMC synthesis and processing and defects in the action of POMC-derived peptides in both humans and mice have helped shape our current understanding of the importance of the melanocortin system in human energy balance.

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