The Lutropin/Choriogonadotropin Receptor, A 2002 Perspective | Zendy

Mario Ascoli | Zendy

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The Lutropin/Choriogonadotropin Receptor, A 2002 Perspective

Author(s) -

Mario Ascoli

Publication year - 2002

Publication title -

endocrine reviews

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.357

H-Index - 272

eISSN - 1945-7189

pISSN - 0163-769X

DOI - 10.1210/er.23.2.141

Subject(s) - ovulation , biology , pregnancy , perspective (graphical) , receptor , reproduction , endocrinology , medicine , ecology , genetics , computer science , artificial intelligence

Reproduction cannot take place without the proper functioning of the lutropin/choriogonadotropin receptor (LHR). When the LHR does not work properly, ovulation does not occur in females and Leydig cells do not develop normally in the male. Also, because the LHR is essential for sustaining the elevated levels of progesterone needed to maintain pregnancy during the first trimester, disruptions in the functions of the LHR during pregnancy have catastrophic consequences. As such, a full understanding of the biology of the LHR is essential to the survival of our species. In this review we summarize our current knowledge of the structure, functions, and regulation of this important receptor

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