Molecular Endocrinology and Physiology of the Aging Central Nervous System | Zendy

Roy G. Smith | Zendy; Lorena Betancourt | Zendy; Yuxiang Sun | Zendy

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Molecular Endocrinology and Physiology of the Aging Central Nervous System

Author(s) -

Roy G. Smith,

Lorena Betancourt,

Yuxiang Sun

Publication year - 2005

Publication title -

endocrine reviews

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.357

H-Index - 272

eISSN - 1945-7189

pISSN - 0163-769X

DOI - 10.1210/er.2002-0017

Subject(s) - neurodegeneration , neuroscience , central nervous system , endocrine system , biology , neuroscientist , cognition , cognitive decline , signal transduction , endocrinology , hormone , medicine , physiology , disease , microbiology and biotechnology , dementia , myelin , oligodendrocyte

Aging is associated with a progressive decline in physical and cognitive functions. The impact of age-dependent endocrine changes regulated by the central nervous system on the dynamics of neuronal behavior, neurodegeneration, cognition, biological rhythms, sexual behavior, and metabolism are reviewed. We also briefly review how functional deficits associated with increases in glucocorticoids and cytokines and declining production of sex steroids, GH, and IGF are likely exacerbated by age-dependent molecular misreading and alterations in components of signal transduction pathways and transcription factors.

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