Mitotane Targets Lipid Droplets to Induce Lipolysis in Adrenocortical Carcinoma | Zendy

Kate Warde | Zendy; Yi Jan Lim | Zendy; Eduardo Ribes Martínez | Zendy; Felix Beuschlein | Zendy; Paula O’Shea | Zendy; Constanze Hantel | Zendy; Michael Conall Dennedy | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Mitotane Targets Lipid Droplets to Induce Lipolysis in Adrenocortical Carcinoma

Author(s) -

Kate Warde,

Yi Jan Lim,

Eduardo Ribes Martínez,

Felix Beuschlein,

Paula O’Shea,

Constanze Hantel,

Michael Conall Dennedy

Publication year - 2022

Publication title -

endocrinology

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.674

H-Index - 257

eISSN - 1945-7170

pISSN - 0013-7227

DOI - 10.1210/endocr/bqac102

Subject(s) - mitotane , adrenocortical carcinoma , lipolysis , lipid droplet , chemistry , endocrinology , medicine , cancer research , biochemistry , biology , adipose tissue

Adrenocortical carcinoma (ACC) is a rare aggressive cancer with low overall survival. Adjuvant mitotane improves survival but is limited by poor response rates and resistance. Mitotane's efficacy is attributed to the accumulation of toxic free cholesterol, predominantly through cholesterol storage inhibition. However, targeting this pathway has proven unsuccessful. We hypothesize that mitotane-induced free-cholesterol accumulation is also mediated through enhanced breakdown of lipid droplets.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research