Sexual Differentiation Specifies Cellular Responses to DNA Damage | Zendy

Lauren Broestl | Zendy; Joshua B. Rubin | Zendy

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Sexual Differentiation Specifies Cellular Responses to DNA Damage

Author(s) -

Lauren Broestl,

Joshua B. Rubin

Publication year - 2021

Publication title -

endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.674

H-Index - 257

eISSN - 1945-7170

pISSN - 0013-7227

DOI - 10.1210/endocr/bqab192

Subject(s) - sexual differentiation , biology , epigenetics , sexual characteristics , sex characteristics , dna damage , dna methylation , hormone , cellular differentiation , physiology , endocrinology , dna , genetics , medicine , gene expression , gene

Significant sex differences exist across cellular, tissue organization, and body system scales to serve the distinct sex-specific functions required for reproduction. They are present in all animals that reproduce sexually and have widespread impacts on normal development, aging, and disease. Observed from the moment of fertilization, sex differences are patterned by sexual differentiation, a lifelong process that involves mechanisms related to sex chromosome complement and the epigenetic and acute activational effects of sex hormones. In this mini-review, we examine evidence for sex differences in cellular responses to DNA damage, their underlying mechanisms, and how they might relate to sex differences in cancer incidence and response to DNA-damaging treatments.

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