Mitochondrial Dysfunction in Obesity and Reproduction | Zendy

Manasi Das | Zendy; Consuelo Sauceda | Zendy; Nicholas J. G. Webster | Zendy

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Mitochondrial Dysfunction in Obesity and Reproduction

Author(s) -

Manasi Das,

Consuelo Sauceda,

Nicholas J. G. Webster

Publication year - 2020

Publication title -

endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.674

H-Index - 257

eISSN - 1945-7170

pISSN - 0013-7227

DOI - 10.1210/endocr/bqaa158

Subject(s) - mitochondrion , biology , pathogenesis , mitochondrial dna , disease , reproduction , endocrinology , apoptosis , obesity , type 2 diabetes , medicine , microbiology and biotechnology , diabetes mellitus , gene , genetics , immunology

Mounting evidence suggests a role for mitochondrial dysfunction in the pathogenesis of many diseases, including type 2 diabetes, aging, and ovarian failure. Because of the central role of mitochondria in energy production, heme biosynthesis, calcium buffering, steroidogenesis, and apoptosis signaling within cells, understanding the molecular mechanisms behind mitochondrial dysregulation and its potential implications in disease is critical. This review will take a journey through the past and summarize what is known about mitochondrial dysfunction in various disorders, focusing on metabolic alterations and reproductive abnormalities. Evidence is presented from studies in different human populations, and rodents with genetic manipulations of pathways known to affect mitochondrial function.

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