Endocrine Significance of SARS-CoV-2’s Reliance on ACE2 | Zendy

Eric Lazartigues | Zendy; Mirza Muhammad Fahd Qadir | Zendy; Franck MauvaisJarvis | Zendy

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Endocrine Significance of SARS-CoV-2’s Reliance on ACE2

Author(s) -

Eric Lazartigues,

Mirza Muhammad Fahd Qadir,

Franck MauvaisJarvis

Publication year - 2020

Publication title -

endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.674

H-Index - 257

eISSN - 1945-7170

pISSN - 0013-7227

DOI - 10.1210/endocr/bqaa108

Subject(s) - covid-19 , endocrine system , endocrinology , medicine , biology , virology , hormone , outbreak , disease , infectious disease (medical specialty)

The current COVID-19 pandemic is the most disruptive event in the past 50 years, with a global impact on health care and world economies. It is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a coronavirus that uses angiotensin-converting enzyme 2 (ACE2) as an entry point to the cells. ACE2 is a transmembrane carboxypeptidase and member of the renin-angiotensin system. This mini-review summarizes the main findings regarding ACE2 expression and function in endocrine tissues. We discuss rapidly evolving knowledge on the potential role of ACE2 and SARS coronaviruses in endocrinology and the development of diabetes mellitus, hypogonadism, and pituitary and thyroid diseases.

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