Unconventional Estrogen Signaling in Health and Disease | Zendy

Christina L Faltas | Zendy; Kira LeBron | Zendy; Marina K. Holz | Zendy

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Unconventional Estrogen Signaling in Health and Disease

Author(s) -

Christina L Faltas,

Kira LeBron,

Marina K. Holz

Publication year - 2020

Publication title -

endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.674

H-Index - 257

eISSN - 1945-7170

pISSN - 0013-7227

DOI - 10.1210/endocr/bqaa030

Subject(s) - estrogen , estrogen receptor , homeostasis , biology , endocrinology , estrogen receptor alpha , transcription factor , signal transduction , medicine , pathogenesis , estrogen receptor beta , hormone , microbiology and biotechnology , gene , cancer , genetics , breast cancer

Estrogen is a key hormone involved in the development and homeostasis of several tissue types in both males and females. By binding estrogen receptors, estrogen regulates essential functions of gene expression, metabolism, cell growth, and proliferation by acting through cytoplasmic signaling pathways or activating transcription in the nucleus. However, disruption or dysregulation of estrogen activity has been shown to play a key role in the pathogenesis and progression of many diseases. This review will expatiate on some of the unconventional roles of estrogen in homeostasis and disease.

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