Murine Germ Cells Do Not Require Functional Androgen Receptors to Complete Spermatogenesis Following Spermatogonial Stem Cell Transplantation | Zendy

Daniel St Johnston | Zendy; Lonnie D. Russell | Zendy; Patrick J. Friel | Zendy; Michael D. Griswold | Zendy

Open Access

Murine Germ Cells Do Not Require Functional Androgen Receptors to Complete Spermatogenesis Following Spermatogonial Stem Cell Transplantation

Author(s) -

Daniel St Johnston,

Lonnie D. Russell,

Patrick J. Friel,

Michael D. Griswold

Publication year - 2001

Publication title -

endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.674

H-Index - 257

eISSN - 1945-7170

pISSN - 0013-7227

DOI - 10.1210/endo.142.6.8317

Subject(s) - spermatogenesis , androgen receptor , transplantation , biology , germ cell , medicine , endocrinology , stem cell , receptor , androgen , andrology , microbiology and biotechnology , prostate cancer , hormone , genetics , gene , cancer

The spermatogonial stem cell transplantation technique was employed to determine if murine germ cells require functional androgen receptors to complete qualitatively normal spermatogenesis. Testicular cells from testicular feminized mice were injected into the seminiferous tubules of azoospermic mice expressing functional androgen receptors. Recipient testes were analyzed between 110 and 200 days following transplantation. Multiple colonies of complete and qualitatively normal donor-derived spermatogenesis were seen within the seminiferous tubules of each recipient testis, demonstrating that murine germ cells do not require functional androgen receptors to complete spermatogenesis.

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