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The disruptive effects of severe stress on reproductive function are well documented, but surprisingly few studies exist that demonstrate milder psychosocial stressors interfere with the ovarian cycle in females. We hypothesized repeated application of psychosocial stress would disrupt estrous cycles in mice. Mice were transferred to a new cage, transported to a new room, and restrained (2 hours) for 21 consecutive days. Contrary to our hypothesis, this paradigm did not affect estrous cycles. We next tested the hypothesis that a single exposure to mild stress disrupts a specific aspect of the cycle: the proestrous luteinizing hormone (LH) surge. We developed a model of acute, layered psychosocial stress (sequential application of new cage, transport to new room, restraint and predator cues lasting 5 hours total) that consistently increased circulating corticosterone. Application of this stress paradigm on midmorning of proestrus disrupted the LH surge measured near lights out in 14 of 24 mice; there was no evidence for a 24-hour delay of the surge. Following stress, mice continued to have normal estrous cycles, even when the LH surge was disrupted. Stressed mice failing to exhibit an LH surge had uterine masses suggesting the proestrous estradiol rise occurred. To test specifically whether the layered stress paradigm blocks estradiol-dependent positive feedback mechanisms, we examined the estradiol-induced LH surge. Stress blocked the estradiol-induced LH surge in all mice. These results suggest exposure to mild, acute psychosocial stress on proestrus can severely disrupt the generation of the LH surge in mice without affecting the overall estrous cycle.

Exposure to Acute Psychosocial Stress Disrupts the Luteinizing Hormone Surge Independent of Estrous Cycle Alterations in Female Mice