The Placenta, a Transducer Linking Maternal Nutrition to Adult Disease in the Offspring? | Zendy

Roger Smith | Zendy; Kaushik Maiti | Zendy

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The Placenta, a Transducer Linking Maternal Nutrition to Adult Disease in the Offspring?

Author(s) -

Roger Smith,

Kaushik Maiti

Publication year - 2012

Publication title -

endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.674

H-Index - 257

eISSN - 1945-7170

pISSN - 0013-7227

DOI - 10.1210/en.2012-1010

Subject(s) - offspring , placenta , endocrinology , pregnancy , medicine , physiology , fetus , biology , genetics

This month's Journal carries an article from Shanghai on the regulation of glucose transporters (GLUT) in human placenta (1). The studies bring a possible new player into the ongoing drama of nutritional regulation of fetal growth and development. The in vitro studies by Gao et al. (1) examined the effects of CRH on mRNA and protein concentrations of GLUT1 and GLUT3. Using a variety of techniques, including small interfering RNA for the corticotrophin releasing hormone receptor type 1 (CRH-R1) receptor, antibodies to the receptor, and receptor blockers, the studies convincingly show that CRH stimulates trophoblast production of GLUT1 and inhibits the expression of GLUT3 via the CRH-R1 receptor

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