Minireview: Roles of the Forkhead Transcription Factor FOXL2 in Granulosa Cell Biology and Pathology | Zendy

Margareta D. Pisarska | Zendy; Gillian Barlow | Zendy; FangTing Kuo | Zendy

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Minireview: Roles of the Forkhead Transcription Factor FOXL2 in Granulosa Cell Biology and Pathology

Author(s) -

Margareta D. Pisarska,

Gillian Barlow,

FangTing Kuo

Publication year - 2011

Publication title -

endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.674

H-Index - 257

eISSN - 1945-7170

pISSN - 0013-7227

DOI - 10.1210/en.2010-1041

Subject(s) - forkhead transcription factors , transcription factor , biology , granulosa cell , regulator , ovary , microbiology and biotechnology , premature ovarian failure , ovarian follicle , anti müllerian hormone , medicine , endocrinology , genetics , hormone , gene

The forkhead transcription factor (FOXL2) is an essential transcription factor in the ovary. It is important in ovarian development and a key factor in female sex determination. In addition, FOXL2 plays a significant role in the postnatal ovary and follicle maintenance. The diverse transcriptional activities of FOXL2 are likely attributable to posttranslational modifications and binding to other key proteins involved in granulosa cell function. Mutations of FOXL2 lead to disorders of ovarian function ranging from premature follicle depletion and ovarian failure to unregulated granulosa cell proliferation leading to tumor formation. Thus, FOXL2 is a key regulator of granulosa cell function and a master transcription factor in these cells.

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