Minireview: Adenosine 5′-Monophosphate-Activated Protein Kinase Regulation of Fatty Acid Oxidation in Skeletal Muscle | Zendy

Megan E. Osler | Zendy; Juleen R. Zierath | Zendy

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Minireview: Adenosine 5′-Monophosphate-Activated Protein Kinase Regulation of Fatty Acid Oxidation in Skeletal Muscle

Author(s) -

Megan E. Osler,

Juleen R. Zierath

Publication year - 2007

Publication title -

endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.674

H-Index - 257

eISSN - 1945-7170

pISSN - 0013-7227

DOI - 10.1210/en.2007-1441

Subject(s) - ampk , anabolism , protein kinase a , amp activated protein kinase , beta oxidation , catabolism , skeletal muscle , endocrinology , adenosine monophosphate , adenosine , medicine , regulator , microbiology and biotechnology , chemistry , biology , kinase , biochemistry , metabolism , gene

AMP-activated protein kinase (AMPK) is master regulator of energy balance through suppression of ATP-consuming anabolic pathways and enhancement of ATP-producing catabolic pathways. AMPK is activated by external metabolic stresses and subsequently orchestrates a complex downstream signaling cascade that mobilizes the cell for efficient energy production. AMPK has emerged as a key kinase driving lipid oxidation in skeletal muscle, and this function has important implications for exercise adaptations as well as metabolic defects associated with obesity.

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