Minireview: Ribonucleic Acid Interference for the Identification of New Targets for the Treatment of Metabolic Diseases | Zendy

Cristina M. Rondi | Zendy

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Minireview: Ribonucleic Acid Interference for the Identification of New Targets for the Treatment of Metabolic Diseases

Author(s) -

Cristina M. Rondi

Publication year - 2006

Publication title -

endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.674

H-Index - 257

eISSN - 1945-7170

pISSN - 0013-7227

DOI - 10.1210/en.2006-0147

Subject(s) - rna interference , computational biology , biology , bioinformatics , identification (biology) , interference (communication) , gene , diabetes mellitus , rna , genetics , computer science , endocrinology , computer network , channel (broadcasting) , botany

Over the past years, RNA interference (RNAi) has exploded as a new approach to manipulate gene expression in mammalian systems. More recently, RNAi has acquired interest as a tool to identify new targets for therapeutic intervention. This review focuses on the current understanding of RNAi biology, how RNAi has been used to study the role of different genes in the pathogenesis of diabetes and obesity, and the use of RNAi screens for the identification of new targets for metabolic diseases. Also reviewed are the in vivo proof of principle experiments that provide the validation of these new targets for the development of RNAi-based therapeutics for diabetes.

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