Minireview: RET: Normal and Abnormal Functions | Zendy

Massimo Santoro | Zendy; Rosa Marina Melillo | Zendy; Francesca Carlomagno | Zendy; Giancarlo Vecchio | Zendy; Alfredo Fusco | Zendy

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Minireview: RET: Normal and Abnormal Functions

Author(s) -

Massimo Santoro,

Rosa Marina Melillo,

Francesca Carlomagno,

Giancarlo Vecchio,

Alfredo Fusco

Publication year - 2004

Publication title -

endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.674

H-Index - 257

eISSN - 1945-7170

pISSN - 0013-7227

DOI - 10.1210/en.2004-0922

Subject(s) - multiple endocrine neoplasia type 2 , proto oncogene proteins c ret , thyroid carcinoma , ret proto oncogene , medullary carcinoma , multiple endocrine neoplasia , germline , tyrosine kinase , medicine , endocrinology , medullary cavity , cancer research , thyroid , endocrine system , cancer , biology , thyroid cancer , germline mutation , mutation , gene , receptor , genetics , hormone , neurotrophic factors , glial cell line derived neurotrophic factor

The RET gene encodes a single-pass transmembrane receptor tyrosine kinase. RET is the oncogene that causes papillary thyroid carcinoma and medullary thyroid carcinoma. The latter may arise as a component of multiple endocrine neoplasia type 2 syndromes; germline mutations in RET are responsible for multiple endocrine neoplasia type 2 inheritance. In this report we review data on the mechanisms leading to RET oncogenic conversion and on RET targeting as a strategy in thyroid cancer treatment.

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