Coenzyme Q Induces Nigral Mitochondrial Uncoupling and Prevents Dopamine Cell Loss in a Primate Model of Parkinson’s Disease | Zendy

Tamas L. Horváth | Zendy; Sabrina Diano | Zendy; Csaba Léránth | Zendy; Luis Miguel GarcíaSegura | Zendy; Michael A. Cowley | Zendy; Marya Shanabrough | Zendy; John D. Elsworth | Zendy; Péter Sótonyi | Zendy; Robert H. Roth | Zendy; Edwin H. Dietrich | Zendy; Russel T. Matthews | Zendy; Colin J. Barnstable | Zendy; D. Eugene Redmond | Zendy

Open Access

Coenzyme Q Induces Nigral Mitochondrial Uncoupling and Prevents Dopamine Cell Loss in a Primate Model of Parkinson’s Disease

Author(s) -

Tamas L. Horváth,

Sabrina Diano,

Csaba Léránth,

Luis Miguel GarcíaSegura,

Michael A. Cowley,

Marya Shanabrough,

John D. Elsworth,

Péter Sótonyi,

Robert H. Roth,

Edwin H. Dietrich,

Russel T. Matthews,

Colin J. Barnstable,

D. Eugene Redmond

Publication year - 2003

Publication title -

endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.674

H-Index - 257

eISSN - 1945-7170

pISSN - 0013-7227

DOI - 10.1210/en.2003-0163

Subject(s) - mptp , dopamine , substantia nigra , neurotoxin , endocrinology , medicine , mitochondrion , parkinson's disease , biology , chemistry , biochemistry , disease , dopaminergic

Parkinson's disease is characterized by dopamine cell loss of the substantia nigra. Parkinson's disease and the neurotoxin 1-methyl-4-phenyl-1,2,5,6 tetrahydropyridine may destroy dopamine neurons through oxidative stress. Coenzyme Q is a cofactor of mitochondrial uncoupling proteins that enhances state-4 respiration and eliminate superoxides. Here we report that short-term oral administration of coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss after 1-methyl-4-phenyl-1,2,5,6 tetrahydropyridine administration in monkeys.

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