Suppressor of Cytokine Signaling 3 Is Induced by Angiotensin II in Heart and Isolated Cardiomyocytes, and Participates in Desensitization | Zendy

Vivian C. Calegari | Zendy; Rosângela Maria Neves Bezerra | Zendy; Márcio Alberto Torsoni | Zendy; Adriana Souza Torsoni | Zendy; Kleber G. Franchini | Zendy; Mário J. A. Saad | Zendy; Lı́cio A. Velloso | Zendy

Open Access

Suppressor of Cytokine Signaling 3 Is Induced by Angiotensin II in Heart and Isolated Cardiomyocytes, and Participates in Desensitization

Author(s) -

Vivian C. Calegari,

Rosângela Maria Neves Bezerra,

Márcio Alberto Torsoni,

Adriana Souza Torsoni,

Kleber G. Franchini,

Mário J. A. Saad,

Lı́cio A. Velloso

Publication year - 2003

Publication title -

endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.674

H-Index - 257

eISSN - 1945-7170

pISSN - 0013-7227

DOI - 10.1210/en.2003-0046

Subject(s) - socs3 , angiotensin ii , endocrinology , medicine , janus kinase , signal transduction , angiotensin ii receptor type 1 , stat protein , suppressor of cytokine signaling 1 , biology , receptor , cytokine , stat3 , chemistry , microbiology and biotechnology , suppressor , cancer

Angiotensin II (Ang II) exerts a potent growth stimulus on the heart and vascular wall. Activation of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) intracellular signaling pathway by Ang II mediates at least some of the mitogenic responses to this hormone. In other signaling systems that use the JAK/STAT pathway, proteins of the suppressor of cytokine signaling (SOCS) family participate in signal regulation. In the present study it is demonstrated that SOCS3 is constitutively expressed at a low level in rat heart and neonatal rat ventricular myocytes. Ang II at a physiological concentration enhances the expression of SOCS3 mRNA and protein, mainly via AT1 receptors. After induction, SOCS3 associates with JAK2 and impairs further activation of the JAK2/STAT1 pathway. Pretreatment of rats with a specific phosphorthioate antisense oligonucleotide to SOCS3, reverses the desensitization to angiotensin signaling, as detected by a fall in c-Jun expression after repetitive infusions of the hormone. Thus, SOCS3 is induced by Ang II in rat heart and neonatal rat ventricular myocytes and participates in the modulation of the signal generated by this hormone.

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