Castration-Induced Apoptosis in the Rat Ventral Prostate Is Associated with Increased Expression of Genes Encoding Insulin-Like Growth Factor Binding Proteins 2, 3, 4 and 5 | Zendy

T Nickerson | Zendy

Open Access

Castration-Induced Apoptosis in the Rat Ventral Prostate Is Associated with Increased Expression of Genes Encoding Insulin-Like Growth Factor Binding Proteins 2, 3, 4 and 5

Author(s) -

T Nickerson

Publication year - 1998

Publication title -

endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.674

H-Index - 257

eISSN - 1945-7170

pISSN - 0013-7227

DOI - 10.1210/en.139.2.807

Subject(s) - castration , endocrinology , medicine , clusterin , involution (esoterism) , prostate , androgen , apoptosis , orchiectomy , biology , prostate cancer , androgen receptor , insulin like growth factor , gene expression , growth factor , receptor , gene , hormone , cancer , consciousness , biochemistry , neuroscience

Insulin-like growth factor binding proteins (IGFBPs) have recently been demonstrated to act as regulators of apoptosis in vitro in both prostate and breast cancer cell lines. We show here that gene expression of IGFBP-2,-3,-4 and -5 increase rapidly in the rat ventral prostate following castration. Increase in IGFBP and mRNA levels were detectable by Northern blotting by 6 hours and reached 5 to 10 fold of control levels at 72 hours after 2/clusterin

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