Maternal Glucocorticoid Metabolism Across Pregnancy: A Potential Mechanism Underlying Fetal Glucocorticoid Exposure
Author(s) -
David Q. Stoye,
Ruth Andrew,
William A. Grobman,
Emma K. Adam,
Pathik D. Wadhwa,
Claudia Buß,
Sonja Entringer,
Gregory E. Miller,
James P. Boardman,
Jonathan R. Seckl,
Lauren KeenanDevlin,
Ann Borders,
Rebecca M. Reynolds
Publication year - 2020
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/clinem/dgz313
Subject(s) - endocrinology , medicine , glucocorticoid , pregnancy , offspring , excretion , urinary system , fetus , urine , birth weight , biology , genetics
Across pregnancy, maternal serum cortisol levels increase up to 3-fold. It is not known whether maternal peripheral cortisol metabolism and clearance change across pregnancy or influence fetal cortisol exposure and development.
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