Parathyroid Hormone and Plasma Phosphate Are Predictors of Soluble α-Klotho Levels in Adults of European Descent | Zendy

Nasser A. Dhayat | Zendy; Menno Pruijm | Zendy; Belén Ponte | Zendy; Daniel Ackermann | Zendy; Alexander Leichtle | Zendy; Olivier Devuyst | Zendy; Georg Ehret | Zendy; Idris Guessous | Zendy; Antoinette Péchère-Bertschi | Zendy; Johanne Pastor | Zendy; PierreYves Martin | Zendy; Michel Burnier | Zendy; Martin Fiedler | Zendy; Bruno Vogt | Zendy; Orson W. Moe | Zendy; Murielle Bochud | Zendy; Daniel G. Fuster | Zendy

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Parathyroid Hormone and Plasma Phosphate Are Predictors of Soluble α-Klotho Levels in Adults of European Descent

Author(s) -

Nasser A. Dhayat,

Menno Pruijm,

Belén Ponte,

Daniel Ackermann,

Alexander Leichtle,

Olivier Devuyst,

Georg Ehret,

Idris Guessous,

Antoinette Péchère-Bertschi,

Johanne Pastor,

PierreYves Martin,

Michel Burnier,

Martin Fiedler,

Bruno Vogt,

Orson W. Moe,

Murielle Bochud,

Daniel G. Fuster

Publication year - 2019

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/clinem/dgz232

Subject(s) - klotho , fibroblast growth factor 23 , endocrinology , medicine , parathyroid hormone , vitamin d and neurology , population , ectodomain , context (archaeology) , bone remodeling , chemistry , receptor , biology , kidney , calcium , paleontology , environmental health

α-klotho is an integral membrane protein that serves as a coreceptor for fibroblast growth factor 23 (FGF23) in conjunction with cognate fibroblast growth factor receptors. Proteolytic cleavage sheds the ectodomain of α-klotho (soluble α-klotho) as an endocrine substance into blood, urine, and cerebrospinal fluid.

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