Open AccessThe Genetic Basis of Thyroid Function: Novel Findings and New Approaches
Author(s) -
Aleksander Kuś,
Layal Chaker,
Alexander Teumer,
Robin P. Peeters,
Marco Medici
Publication year - 2020
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/clinem/dgz225
Subject(s) - mendelian randomization , genome wide association study , thyroid , genetic association , thyroid function , context (archaeology) , medicine , hormone , biology , bioinformatics , endocrinology , genetics , genetic variants , gene , single nucleotide polymorphism , genotype , paleontology
Genetic factors are major determinants of thyroid function. Over the last two decades, multiple genetic variants have been associated with variations in normal range thyroid function tests. Most recently, a large-scale genome-wide association study (GWAS) doubled the number of known variants associated with normal range thyrotropin (TSH) and free thyroxine (FT4) levels.
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