Prenatal Exposure to Bisphenols and Phthalates and Postpartum Depression: The Role of Neurosteroid Hormone Disruption | Zendy

Melanie H. Jacobson | Zendy; Cheryl R. Stein | Zendy; Mengling Liu | Zendy; Marra Ackerman | Zendy; Jennifer K. Blakemore | Zendy; Sara E. Long | Zendy; Graziano Pinna | Zendy; Raquel Romay-Tallón | Zendy; Kurunthachalam Kannan | Zendy; Hongkai Zhu | Zendy; Leonardo Trasande | Zendy

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Prenatal Exposure to Bisphenols and Phthalates and Postpartum Depression: The Role of Neurosteroid Hormone Disruption

Author(s) -

Melanie H. Jacobson,

Cheryl R. Stein,

Mengling Liu,

Marra Ackerman,

Jennifer K. Blakemore,

Sara E. Long,

Graziano Pinna,

Raquel Romay-Tallón,

Kurunthachalam Kannan,

Hongkai Zhu,

Leonardo Trasande

Publication year - 2021

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/clinem/dgab199

Subject(s) - neuroactive steroid , depression (economics) , prenatal exposure , postpartum depression , bisphenol a , pregnancy , endocrinology , medicine , hormone , obstetrics , chemistry , biology , gestation , receptor , economics , genetics , organic chemistry , gabaa receptor , epoxy , macroeconomics

Postpartum depression (PPD) is a serious psychiatric disorder. While causes remain poorly understood, perinatal sex hormone fluctuations are an important factor, and allopregnanolone in particular has emerged as a key determinant. Although synthetic environmental chemicals such as bisphenols and phthalates are known to affect sex hormones, no studies have measured allopregnanolone and the consequences of these hormonal changes on PPD have not been interrogated.

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