Open AccessProgesterone Receptors Promote Quiescence and Ovarian Cancer Cell Phenotypes via DREAM in p53-Mutant Fallopian Tube Models
Author(s) -
Laura J. Mauro,
Megan Seibel,
Caroline H. Diep,
Angela Spartz,
Carlos Perez Kerkvliet,
Hari Singhal,
Elizabeth M. Swisher,
Lauren E. Schwartz,
Ronny Drapkin,
Siddharth Saini,
Fatmata Sesay,
Larisa Litovchick,
Carol A. Lange
Publication year - 2021
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/clinem/dgab195
Subject(s) - biology , ovarian cancer , cancer research , progesterone receptor , serous carcinoma , fallopian tube , context (archaeology) , cell cycle , microbiology and biotechnology , cancer , genetics , estrogen receptor , anatomy , breast cancer , paleontology
The ability of ovarian steroids to modify ovarian cancer (OC) risk remains controversial. Progesterone is considered to be protective; recent studies indicate no effect or enhanced OC risk. Knowledge of progesterone receptor (PR) signaling during altered physiology that typifies OC development is limited.
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