Physical Activity, Genetic Susceptibility, and the Risk of Latent Autoimmune Diabetes in Adults and Type 2 Diabetes | Zendy

Rebecka Hjort | Zendy; Emma Ahlqvist | Zendy; Tomas Andersson | Zendy; Lars Alfredsson | Zendy; Per-Ola Carlsson | Zendy; Valdemar Grill | Zendy; Leif Groop | Zendy; Mats Martinell | Zendy; Elin Pettersen Sørgjerd | Zendy; Jaakko Tuomilehto | Zendy; Bjørn Olav Åsvold | Zendy; Sofia Carlsson | Zendy

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Physical Activity, Genetic Susceptibility, and the Risk of Latent Autoimmune Diabetes in Adults and Type 2 Diabetes

Author(s) -

Rebecka Hjort,

Emma Ahlqvist,

Tomas Andersson,

Lars Alfredsson,

Per-Ola Carlsson,

Valdemar Grill,

Leif Groop,

Mats Martinell,

Elin Pettersen Sørgjerd,

Jaakko Tuomilehto,

Bjørn Olav Åsvold,

Sofia Carlsson

Publication year - 2020

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/clinem/dgaa549

Subject(s) - medicine , type 2 diabetes , tcf7l2 , diabetes mellitus , body mass index , endocrinology , relative risk , obesity , incidence (geometry) , prospective cohort study , genotype , single nucleotide polymorphism , confidence interval , biology , gene , biochemistry , physics , optics

Physical activity (PA) has been linked to a reduced risk of type 2 diabetes by reducing weight and improving insulin sensitivity. We investigated whether PA is associated with a lower incidence of latent autoimmune diabetes in adults (LADA) and whether the association is modified by genotypes of human leukocyte antigen (HLA), transcription factor 7-like 2 (TCF7L2)-rs7903146, or the fat mass and obesity-associated gene, FTO-rs9939609.

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