New Horizons: Novel Adrenal Regenerative Therapies | Zendy

Stefan R. Bornstein | Zendy; Maria Malyukov | Zendy; Carolin Heller | Zendy; Christian G. Ziegler | Zendy; Gerard RuizBabot | Zendy; Andreas Schedl | Zendy; Barbara Ludwig | Zendy; Charlotte Steenblock | Zendy

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New Horizons: Novel Adrenal Regenerative Therapies

Author(s) -

Stefan R. Bornstein,

Maria Malyukov,

Carolin Heller,

Christian G. Ziegler,

Gerard RuizBabot,

Andreas Schedl,

Barbara Ludwig,

Charlotte Steenblock

Publication year - 2020

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/clinem/dgaa438

Subject(s) - regenerative medicine , medicine , adrenal cortex , disease , neuroscience , new horizons , bioinformatics , adrenal insufficiency , stem cell , intensive care medicine , biology , genetics , engineering , spacecraft , aerospace engineering

Adrenal insufficiency requires lifelong corticoid replacement therapies. However, current therapies are not able to replace the physiological circadian pattern of the adrenal cortex and are associated with many metabolic, vascular, neuroendocrine, and mental perturbations. Therefore, regenerative and more curative strategies would be desirable. In the current perspective, we describe emerging new regenerative therapies for the treatment of adrenal insufficiency. In particular, we discuss gene therapy and cell replacement strategies. Furthermore, we discuss how adrenal cells might be used as a source for regenerative therapies of nonadrenal neurodegenerative diseases such as Parkinson disease.

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