Open AccessFamilial Longevity is Associated with an Attenuated Thyroidal Response to Recombinant Human Thyroid Stimulating Hormone
Author(s) -
Ana Zutinic,
Hanno Pijl,
Bart E.P.B. Ballieux,
Ferdinand Roelfsema,
Rudi G. J. Westendorp,
Gerard J. Blauw,
Diana van Heemst
Publication year - 2020
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/clinem/dgaa195
Subject(s) - thyroid , recombinant dna , longevity , hormone , endocrinology , medicine , thyroid stimulating hormone , human growth hormone , biology , growth hormone , gerontology , gene , genetics
Longevity is associated with higher circulating levels of TSH in the absence of differences in circulating thyroid hormones (TH), as previously observed in F2 members of long-lived families (F2-LLS) and their partners (F2-Con). The mechanism underlying this observed difference remains unknown.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom