Genomics of Multiple Myeloma | Zendy

Sébastien Robiou du Pont | Zendy; Alice Cleynen | Zendy; Charlotte Fontan | Zendy; Michel Attal | Zendy; Nikhil C. Munshi | Zendy; Jill Corre | Zendy; Hervé AvetLoiseau | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Genomics of Multiple Myeloma

Author(s) -

Sébastien Robiou du Pont,

Alice Cleynen,

Charlotte Fontan,

Michel Attal,

Nikhil C. Munshi,

Jill Corre,

Hervé AvetLoiseau

Publication year - 2017

Publication title -

journal of clinical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.482

H-Index - 548

eISSN - 1527-7755

pISSN - 0732-183X

DOI - 10.1200/jco.2016.70.6705

Subject(s) - neuroblastoma ras viral oncogene homolog , kras , multiple myeloma , cancer research , medicine , chromosomal translocation , gene , exome , exome sequencing , gene expression profiling , genetics , mutation , biology , gene expression , immunology

Multiple myeloma (MM) is characterized by wide variability in the chromosomal/genetic changes present in tumor plasma cells. Genetically, MM can be divided into two groups according to ploidy and hyperdiploidy versus nonhyperdiploidy. Several studies in gene expression profiling attempted to identify subentities in MM without convincing results. These studies mostly confirmed the cytogenetic data and subclassified patients according to 14q32 translocations and ploidy. More-recent data that are based on whole-exome sequencing have confirmed this heterogeneity and show many gene mutations but without a unifying mutation. These newer studies have shown the frequent alteration of the mitogen-activated protein kinase pathway. The most interesting data have demonstrated subclonality in all patients with MM, including subclonal mutations of supposed driver genes KRAS, NRAS, and BRAF.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research