Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog–Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032 | Zendy

Giles Robinson | Zendy; Brent A. Orr | Zendy; Gang Wu | Zendy; Sridharan Gururangan | Zendy; Tong Lin | Zendy; Ibrahim Qaddoumi | Zendy; Roger J. Packer | Zendy; Stewart Goldman | Zendy; Michael D. Prados | Zendy; Annick Desjardins | Zendy; Murali Chintagumpala | Zendy; Naoko Takebe | Zendy; Sue C. Kaste | Zendy; Michael Rusch | Zendy; Sariah J. Allen | Zendy; Arzu OnarThomas | Zendy; Clinton F. Stewart | Zendy; Maryam Fouladi | Zendy; James M. Boyett | Zendy; Richard J. Gilbertson | Zendy; Tom Curran | Zendy; David W. Ellison | Zendy; Amar Gajjar | Zendy

Open Access

Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog–Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032

Author(s) -

Giles Robinson,

Brent A. Orr,

Gang Wu,

Sridharan Gururangan,

Tong Lin,

Ibrahim Qaddoumi,

Roger J. Packer,

Stewart Goldman,

Michael D. Prados,

Annick Desjardins,

Murali Chintagumpala,

Naoko Takebe,

Sue C. Kaste,

Michael Rusch,

Sariah J. Allen,

Arzu OnarThomas,

Clinton F. Stewart,

Maryam Fouladi,

James M. Boyett,

Richard J. Gilbertson,

Tom Curran,

David W. Ellison,

Amar Gajjar

Publication year - 2015

Publication title -

journal of clinical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.482

H-Index - 548

eISSN - 1527-7755

pISSN - 0732-183X

DOI - 10.1200/jco.2014.60.1591

Subject(s) - vismodegib , sonic hedgehog , medulloblastoma , smoothened , medicine , ptch1 , oncology , hedgehog signaling pathway , cancer research , biology , genetics , gene , basal cell carcinoma , basal cell

Two phase II studies assessed the efficacy of vismodegib, a sonic hedgehog (SHH) pathway inhibitor that binds smoothened (SMO), in pediatric and adult recurrent medulloblastoma (MB).

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