Risk Algorithm Using Serial Biomarker Measurements Doubles the Number of Screen-Detected Cancers Compared With a Single-Threshold Rule in the United Kingdom Collaborative Trial of Ovarian Cancer Screening | Zendy

Usha Me | Zendy; Andy Ryan | Zendy; Jatinderpal Kalsi | Zendy; Aleksandra GentryMaharaj | Zendy; Anne Dawnay | Zendy; Mariam Habib | Zendy; Sophia Apostolidou | Zendy; Naveena Singh | Zendy; Elizabeth Benjamin | Zendy; Matthew Burnell | Zendy; S. J. Davies | Zendy; Aarti Sharma | Zendy; Richard Gunu | Zendy; Keith Godfrey | Zendy; Alberto Lopes | Zendy; David Oram | Zendy; Jonathan Herod | Zendy; Karin Williamson | Zendy; Mourad W. Seif | Zendy; Howard J. Jenkins | Zendy; Tim Mould | Zendy; Robert Woolas | Zendy; John Murdoch | Zendy; Stephen Dobbs | Zendy; Nazar N. Amso | Zendy; Simon Leeson | Zendy; Derek Cruickshank | Zendy; Ian Scott | Zendy; Lesley Fallowfield | Zendy; Martin Widschwendter | Zendy; Karina Reynolds | Zendy; Alistair McGuire | Zendy; Stuart Campbell | Zendy; Mahesh Parmar | Zendy; Steven J. Skates | Zendy; Ian Jacobs | Zendy

Open Access

Risk Algorithm Using Serial Biomarker Measurements Doubles the Number of Screen-Detected Cancers Compared With a Single-Threshold Rule in the United Kingdom Collaborative Trial of Ovarian Cancer Screening

Author(s) -

Usha Me,

Andy Ryan,

Jatinderpal Kalsi,

Aleksandra GentryMaharaj,

Anne Dawnay,

Mariam Habib,

Sophia Apostolidou,

Naveena Singh,

Elizabeth Benjamin,

Matthew Burnell,

S. J. Davies,

Aarti Sharma,

Richard Gunu,

Keith Godfrey,

Alberto Lopes,

David Oram,

Jonathan Herod,

Karin Williamson,

Mourad W. Seif,

Howard J. Jenkins,

Tim Mould,

Robert Woolas,

John Murdoch,

Stephen Dobbs,

Nazar N. Amso,

Simon Leeson,

Derek Cruickshank,

Ian Scott,

Lesley Fallowfield,

Martin Widschwendter,

Karina Reynolds,

Alistair McGuire,

Stuart Campbell,

Mahesh Parmar,

Steven J. Skates,

Ian Jacobs

Publication year - 2015

Publication title -

journal of clinical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.482

H-Index - 548

eISSN - 1527-7755

pISSN - 0732-183X

DOI - 10.1200/jco.2014.59.4945

Subject(s) - medicine , ovarian cancer , incidence (geometry) , cancer , biomarker , cancer registry , algorithm , receiver operating characteristic , gynecology , oncology , obstetrics , biochemistry , chemistry , physics , computer science , optics

Cancer screening strategies have commonly adopted single-biomarker thresholds to identify abnormality. We investigated the impact of serial biomarker change interpreted through a risk algorithm on cancer detection rates.

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