Mutational Spectrum, Copy Number Changes, and Outcome: Results of a Sequencing Study of Patients With Newly Diagnosed Myeloma | Zendy

Brian A. Walker | Zendy; Eileen M. Boyle | Zendy; Christopher P. Wardell | Zendy; Alex Murison | Zendy; Dil Begum | Zendy; Nasrin M. Dahir | Zendy; Paula Proszek | Zendy; David C. Johnson | Zendy; Martin Kaiser | Zendy; Lorenzo Melchor | Zendy; Lauren I. Aronson | Zendy; Matthew Scales | Zendy; Charlotte Pawlyn | Zendy; Fabio Mirabella | Zendy; John R Jones | Zendy; Annamaria Brioli | Zendy; Aneta Mikulášová | Zendy; David A. Cairns | Zendy; Walter M. Gregory | Zendy; Ana Quartilho | Zendy; Mark T. Drayson | Zendy; Nigel H. Russell | Zendy; Gordon Cook | Zendy; Graham Jackson | Zendy; Xavier Leleu | Zendy; Faith E. Davies | Zendy; Gareth J. Morgan | Zendy

Open Access

Mutational Spectrum, Copy Number Changes, and Outcome: Results of a Sequencing Study of Patients With Newly Diagnosed Myeloma

Author(s) -

Brian A. Walker,

Eileen M. Boyle,

Christopher P. Wardell,

Alex Murison,

Dil Begum,

Nasrin M. Dahir,

Paula Proszek,

David C. Johnson,

Martin Kaiser,

Lorenzo Melchor,

Lauren I. Aronson,

Matthew Scales,

Charlotte Pawlyn,

Fabio Mirabella,

John R Jones,

Annamaria Brioli,

Aneta Mikulášová,

David A. Cairns,

Walter M. Gregory,

Ana Quartilho,

Mark T. Drayson,

Nigel H. Russell,

Gordon Cook,

Graham Jackson,

Xavier Leleu,

Faith E. Davies,

Gareth J. Morgan

Publication year - 2015

Publication title -

journal of clinical oncology

Language(s) - English

Resource type - Journals

eISSN - 1527-7755

pISSN - 0732-183X

DOI - 10.1200/jco.2014.59.1503

Subject(s) - neuroblastoma ras viral oncogene homolog , kras , medicine , multiple myeloma , oncology , cancer research , exome sequencing , exome , population , mutation , cancer , genetics , gene , biology , colorectal cancer , environmental health

At the molecular level, myeloma is characterized by copy number abnormalities and recurrent translocations into the immunoglobulin heavy chain locus. Novel methods, such as massively parallel sequencing, have begun to describe the pattern of tumor-acquired mutations, but their clinical relevance has yet to be established.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research