Intratumoral Heterogeneity of ALK-Rearranged and ALK/EGFR Coaltered Lung Adenocarcinoma | Zendy

Weijing Cai | Zendy; Dongmei Lin | Zendy; Chunyan Wu | Zendy; Xuefei Li | Zendy; Chao Zhao | Zendy; Li-Mou Zheng | Zendy; Shan Chuai | Zendy; Ke Fei | Zendy; Caicun Zhou | Zendy; Fred R. Hirsch | Zendy

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Intratumoral Heterogeneity of ALK-Rearranged and ALK/EGFR Coaltered Lung Adenocarcinoma

Author(s) -

Weijing Cai,

Dongmei Lin,

Chunyan Wu,

Xuefei Li,

Chao Zhao,

Li-Mou Zheng,

Shan Chuai,

Ke Fei,

Caicun Zhou,

Fred R. Hirsch

Publication year - 2015

Publication title -

journal of clinical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.482

H-Index - 548

eISSN - 1527-7755

pISSN - 0732-183X

DOI - 10.1200/jco.2014.58.8293

Subject(s) - adenocarcinoma , genetic heterogeneity , laser capture microdissection , cancer research , anaplastic lymphoma kinase , microdissection , epidermal growth factor receptor , lung cancer , phenotype , mutation , medicine , pathology , biology , cancer , gene , genetics , gene expression , malignant pleural effusion

Genetic intratumoral heterogeneity has a profound influence on the selection of clinical treatment strategies and on addressing resistance to targeted therapy. The purpose of this study was to explore the potential effect of intratumoral heterogeneity on both genetic and pathologic characteristics of ALK-rearranged lung adenocarcinoma (LADC).

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