Open AccessDonepezil for Irradiated Brain Tumor Survivors: A Phase III Randomized Placebo-Controlled Clinical Trial
Author(s) -
Stephen R. Rapp,
L. D. Case,
Ann M. Peiffer,
Michelle M. Naughton,
Michael D. Chan,
Volker W. Stieber,
Dennis F. Moore,
Steven C. Falchuk,
James Piephoff,
William J. Edenfield,
Jeffrey K. Giguere,
Monica Loghin,
Edward G. Shaw
Publication year - 2015
Publication title -
journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.482
H-Index - 548
eISSN - 1527-7755
pISSN - 0732-183X
DOI - 10.1200/jco.2014.58.4508
Subject(s) - donepezil , medicine , cognition , verbal fluency test , placebo , verbal memory , brain tumor , randomized controlled trial , effects of sleep deprivation on cognitive performance , anesthesia , audiology , neuropsychology , psychiatry , dementia , pathology , alternative medicine , disease
Neurotoxic effects of brain irradiation include cognitive impairment in 50% to 90% of patients. Prior studies have suggested that donepezil, a neurotransmitter modulator, may improve cognitive function.
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